Angewandte Chemie - International Edition
Angewandte Chemie - International Edition
5 years ago

Functional Mechanically Interlocked Molecules: Asymmetric Organocatalysis with a Catenated Bifunctional Brønsted Acid

Functional Mechanically Interlocked Molecules: Asymmetric Organocatalysis with a Catenated Bifunctional Brønsted Acid
Stefan Grimme, Raja Mitra, Hui Zhu, Jochen Niemeyer
A catenane-based organocatalyst shows excellent stereoselectivity in the transfer hydrogenation of quinolines. In their Communication (DOI: 10.1002/anie.201704647), J. Niemeyer and co-workers report the first application of a catenane catalyst in asymmetric catalysis. The bifunctional catenane shows superior stereoselectivity in comparison to its non-interlocked analogues. DFT calculations indicate involvement of both catalytically active groups as the reason for the high stereoselectivity.

Publisher URL: http://onlinelibrary.wiley.com/resolve/doi

DOI: 10.1002/anie.201707711

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