Tetrahedron
Tetrahedron
5 years ago

A concise enantioselective synthesis of pyrrolidine sedum alkaloids (R)-(R)-(+), (S)-(S)-(−)-pyrrolsedamine and (S)-(R)-(+)-pyrrolallosedamine by using proline catalysed α-amination reaction

A concise enantioselective synthesis of pyrrolidine sedum alkaloids (R)-(R)-(+), (S)-(S)-(−)-pyrrolsedamine and (S)-(R)-(+)-pyrrolallosedamine by using proline catalysed α-amination reaction
A general approach for the synthesis of pyrolidine member of sedum alkaloids has been developed by employing proline catalysed sequential α-amination and Horner–Wadsworth–Emmons (HWE) olefination of an aldehyde as the key steps. This method can be extended for the synthesis of various bioactive natural products containing pyrolidine skeleton.

Publisher URL: www.sciencedirect.com/science

DOI: S0040402017307470

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