Tetrahedron
Tetrahedron
5 years ago

“One-pot” sequential preparation of isoquinoline-1,3(2H,4H)-dione derivatives by reacting N-alkyl(aryl)-N-methacryloyl benzamides with benzyl alcohols and sodium benzenesulfinates

“One-pot” sequential preparation of isoquinoline-1,3(2H,4H)-dione derivatives by reacting N-alkyl(aryl)-N-methacryloyl benzamides with benzyl alcohols and sodium benzenesulfinates
Two cascade coupling reactions were developed between N-alkyl(aryl)-N-methacryloyl benzamides and readily available benzyl alcohols or sodium benzenesulfinates. Through a radical cyclization strategy, these one-pot sequential reactions provided two simple and efficient approaches to the synthesis of a variety of isoquinoline-1,3(2H,4H)-dione derivatives in high yields with a broad substrate scope. These compounds are valuable molecules in drug discovery.

Publisher URL: www.sciencedirect.com/science

DOI: S0040402017308062

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