Organic Letters
Organic Letters
5 years ago

Reagent Design and Ligand Evolution for the Development of a Mild Copper-Catalyzed Hydroxylation Reaction

Reagent Design and Ligand Evolution for the Development of a Mild Copper-Catalyzed Hydroxylation Reaction
Patrick S. Fier, Kevin M. Maloney
Parallel synthesis and mass-directed purification of a modular ligand library, high-throughput experimentation, and rational ligand evolution have led to a novel copper catalyst for the synthesis of phenols with a traceless hydroxide surrogate. The mild reaction conditions reported here enable the late-stage synthesis of numerous complex, druglike phenols.

Publisher URL: http://dx.doi.org/10.1021/acs.orglett.7b01403

DOI: 10.1021/acs.orglett.7b01403

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