4 years ago

“Breathing” CO2-, O2-, and Light-Responsive Vesicles from a Triblock Copolymer for Rate-Tunable Controlled Release

“Breathing” CO2-, O2-, and Light-Responsive Vesicles from a Triblock Copolymer for Rate-Tunable Controlled Release
Patrick Theato, Jiaojiao Shang, Xiaoxiao Zhang, Shaojian Lin
A well-defined amphiphilic triblock copolymer, poly[(ethylene glycol)methyl ether]-block-poly(N,N-dimethylamino ethyl methacrylate-co-2,2,2-trifluoroethyl methacrylate)-block-poly(4-(4-methoxy-phenylazo)phenoxy methacrylate) (PEG-b-P(DMAEMA-co-TFEMA)-b-PMEPPMA), is successfully synthesized by stepwise atom transfer radical polymerization. Owing to its amphiphilic nature, PEG-b-P(DMAEMA-co-TFEMA)-b-PMEPPMA can self-assemble into vesicles in aqueous solution and exhibits a reversible triple-responsive behavior toward CO2, O2, and light stimuli. More importantly, such vesicles can exhibit a controlled “breathing” behavior via external stimuli due to their suitable chemical structure and stimuli responsiveness. Consequently, these vesicles can be employed as nanocarriers for rate-tunable controlled release via adjustment of their membrane permeability by a single stimulus or various stimuli combinations. “Breathing” vesicles are self-assembled from a CO2-, O2-, and light-responsive amphiphilic block copolymer in aqueous solution. The size of these vesicles could be reversibly adjusted via addition and removal of external stimuli to present corresponding “breathing” transition behaviors. Based on this feature, these vesicles can exhibit rate-tunable controlled release behavior depending on external stimuli.

Publisher URL: http://onlinelibrary.wiley.com/resolve/doi

DOI: 10.1002/marc.201700313

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