European Polymer Journal
European Polymer Journal
5 years ago

pH-sensitive poly(ortho ester urethanes) copolymers with controlled degradation kinetic: synthesis, characterization, and in vitro evaluation as drug carriers

pH-sensitive poly(ortho ester urethanes) copolymers with controlled degradation kinetic: synthesis, characterization, and in vitro evaluation as drug carriers
Poly(ortho ester urethanes) (POEUs) copolymers were synthesized via polycondensation between the new ortho ester-based diols and hexamethylene diisocyanate (HDI) or dicyclohexylmethane 4,4'-diisocyanate (HMDI) with flexible or rigid chain, which was introduced to regulate the degradation kinetic of POEUs, and designed as POEU1 or POEU2, respectively. POEU1 and POEU2 could form nanoparticles using an oil-in-water single emulsion, which is named as NP1 and NP2, respectively. In vitro degradation experiment shows that NP1 prepared from POEU1 with flexible chains has a degradation half-life of 5.0 h at pH 5.0 whereas NP2 prepared from POEU2 with rigid chains has a degradation half-life of 16.2 h. Doxorubicin (DOX) was then loaded into these nanoparticles and designed as NP1/DOX and NP2/DOX for evaluating the antitumor effect. NP1/DOX with faster acid-triggered drug release can be more efficiently internalized by two-dimensional (2D) cells and three-dimensional (3D) multicellular tumor spheroids (MCTS), and lead to improved antitumor efficiency.

Publisher URL: www.sciencedirect.com/science

DOI: S001430571730681X

You might also like
Discover & Discuss Important Research

Keeping up-to-date with research can feel impossible, with papers being published faster than you'll ever be able to read them. That's where Researcher comes in: we're simplifying discovery and making important discussions happen. With over 19,000 sources, including peer-reviewed journals, preprints, blogs, universities, podcasts and Live events across 10 research areas, you'll never miss what's important to you. It's like social media, but better. Oh, and we should mention - it's free.

  • Download from Google Play
  • Download from App Store
  • Download from AppInChina

Researcher displays publicly available abstracts and doesn’t host any full article content. If the content is open access, we will direct clicks from the abstracts to the publisher website and display the PDF copy on our platform. Clicks to view the full text will be directed to the publisher website, where only users with subscriptions or access through their institution are able to view the full article.