3 years ago

Ruthenium-Catalyzed 1,6-Aromatic Enamide–Silylalkyne Cycloisomerization: Approach to 2,3-Disubstituted Indoles

Ruthenium-Catalyzed 1,6-Aromatic Enamide–Silylalkyne Cycloisomerization: Approach to 2,3-Disubstituted Indoles
Kohei Takamoto, Shohei Ohno, Hiromichi Fujioka, Norimichi Hyogo, Mitsuhiro Arisawa
Cycloisomerization is an atom economic procedure that converts dienes and enynes into cyclic molecules. To date, cycloisomerization between enamides and silylalkynes has not been explored. We found that N-acyl-N-vinyl-2-silylalkynylaniline derivatives undergo a cycloisomerization in the presence of a well-defined ruthenium hydride to give a 2,3-disubstitued indole. The vinyl and silylmethyl substituents on the 2- and 3-positions of the indole can be easily converted to other functional groups.

Publisher URL: http://dx.doi.org/10.1021/acs.joc.7b01288

DOI: 10.1021/acs.joc.7b01288

You might also like
Discover & Discuss Important Research

Keeping up-to-date with research can feel impossible, with papers being published faster than you'll ever be able to read them. That's where Researcher comes in: we're simplifying discovery and making important discussions happen. With over 19,000 sources, including peer-reviewed journals, preprints, blogs, universities, podcasts and Live events across 10 research areas, you'll never miss what's important to you. It's like social media, but better. Oh, and we should mention - it's free.

  • Download from Google Play
  • Download from App Store
  • Download from AppInChina

Researcher displays publicly available abstracts and doesn’t host any full article content. If the content is open access, we will direct clicks from the abstracts to the publisher website and display the PDF copy on our platform. Clicks to view the full text will be directed to the publisher website, where only users with subscriptions or access through their institution are able to view the full article.