ACS Macro Letters
ACS Macro Letters
5 years ago

Probing the Surfaces of Biomacromolecules with Polymer-Scaffolded Dynamic Combinatorial Libraries

Probing the Surfaces of Biomacromolecules with Polymer-Scaffolded Dynamic Combinatorial Libraries
Matthew A. Dobson, Andrew T. Turley, Antonio J. Ruiz-Sanchez, David A. Fulton, Adam J. North, Patrick L. Higgs, Daniel T. Peters
Methods to analyze and compare biomacromolecular surfaces are still in their relative infancy on account of the challenges involved in comparing surfaces computationally. We describe a systems chemistry approach that utilizes polymer-scaffolded dynamic combinatorial libraries to experimentally probe biomacromolecular surfaces in aqueous solution which provides feedback as to the nature of the surfaces, allowing the comparison of three globular proteins and a nucleic acid.

Publisher URL: http://dx.doi.org/10.1021/acsmacrolett.7b00561

DOI: 10.1021/acsmacrolett.7b00561

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