3 years ago

Palladium-Catalyzed sp2–sp3 Coupling of Chloromethylarenes with Allyltrimethoxysilane: Synthesis of Allyl Arenes

Palladium-Catalyzed sp2–sp3 Coupling of Chloromethylarenes with Allyltrimethoxysilane: Synthesis of Allyl Arenes
Ming Bao, Sheng Zhang, Jinfang Cai, Yoshinori Yamamoto
Palladium-catalyzed remote sp2–sp3 coupling reaction of chloromethylarenes with allyltrimethoxysilane is described in this work. The allylation reaction regioselectively occurred on the para-positions of 1-(chloromethyl)naphthalenes and benzyl chlorides to form new C(sp2)–C(sp3) bonds. The reaction proceeds smoothly under mild conditions to produce allyl arenes in moderate to excellent yields.

Publisher URL: http://dx.doi.org/10.1021/acs.joc.7b00678

DOI: 10.1021/acs.joc.7b00678

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