3 years ago

Visible-Light-Mediated Monoselective Ortho C–H Arylation of 6-Arylpurine Nucleosides with Diazonium Salts

Visible-Light-Mediated Monoselective Ortho C–H Arylation of 6-Arylpurine Nucleosides with Diazonium Salts
Hai-Ming Guo, Ming-Sheng Xie, Hong-Ying Niu, Lei Liang, Gui-Rong Qu, Hai-Xia Wang
A combined palladium- and photoredox-catalyzed monoselective arylation of 6-arylpurine nucleosides has been developed by employing purine as a directing group via the photoredox reaction, and many functional groups are well tolerated in this direct C–H arylation condition. Various of functionalized purines (nucleosides) which are potentially of great importance in medicinal chemistry could be obtained under visible light irradiation at room temperature within 4 h.

Publisher URL: http://dx.doi.org/10.1021/acs.joc.7b00659

DOI: 10.1021/acs.joc.7b00659

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