3 years ago

Inside Cover: An Optimized Two-Photon Fluorescent Probe for Biological Sensing and Imaging of Catechol-O-Methyltransferase (Chem. Eur. J. 45/2017)

Inside Cover: An Optimized Two-Photon Fluorescent Probe for Biological Sensing and Imaging of Catechol-O-Methyltransferase (Chem. Eur. J. 45/2017)
Xing-Kai Qian, Yang Yu, Qun Luo, Tong-Yi Dou, Ling Yang, Li-Wei Zou, Shi-Yang Li, Dan-Dan Wang, Qiang Jin, Ping Wang, Yang-Liu Xia, Guang-Bo Ge
A highly sensitive and selective two-photon fluorescence probe for catechol-O-methyltransferase (COMT) was developed via regioselective masking of one hydroxyl group of the substrates. The probe served as an efficient tool for biological sensing and bio-imaging of COMT in complex biological systems, as well as for high-throughput screening of COMT inhibitors. The strategy used in this study also sheds new light on the development of fluorescent probes for other conjugative enzymes. More information can be found in the Full Paper by G.-B. Ge, L. Yang et al. on page 10800.

Publisher URL: http://onlinelibrary.wiley.com/resolve/doi

DOI: 10.1002/chem.201702637

You might also like
Discover & Discuss Important Research

Keeping up-to-date with research can feel impossible, with papers being published faster than you'll ever be able to read them. That's where Researcher comes in: we're simplifying discovery and making important discussions happen. With over 19,000 sources, including peer-reviewed journals, preprints, blogs, universities, podcasts and Live events across 10 research areas, you'll never miss what's important to you. It's like social media, but better. Oh, and we should mention - it's free.

  • Download from Google Play
  • Download from App Store
  • Download from AppInChina

Researcher displays publicly available abstracts and doesn’t host any full article content. If the content is open access, we will direct clicks from the abstracts to the publisher website and display the PDF copy on our platform. Clicks to view the full text will be directed to the publisher website, where only users with subscriptions or access through their institution are able to view the full article.