3 years ago

Morphological control and properties of poly(lactic acid) hollow fibers for biomedical applications

Morphological control and properties of poly(lactic acid) hollow fibers for biomedical applications
Cristiano Piacsek Borges, Rui Carlos Castro Domingues, Cristina Cardoso Pereira
Poly(lactic acid) (PLA) hollow-fiber (HF) membranes were prepared by wet spinning with a phase-inversion technique. Dimethyl sulfoxide (DMSO), N-methyl-2-pyrrolidone (NMP), and 1,4-dioxane (DIO) were applied as solvents (Ss), and water was applied as a nonsolvent in the precipitation bath. The polymer solution viscosities, PLA–S–water miscibility regions, and precipitation onsets were measured and related to the Hansen solubility and Flory–Huggins interaction parameters. We observed a morphological transition from fingerlike to spongelike pores when DIO was applied as the S instead NMP or DMSO. The water permeabilities of these membranes were not detectable at a transmembrane pressure of 1 bar, and higher pressures caused them mechanical damage. However, the addition of 5 wt % poly(vinyl pyrrolidone) (PVP) induced a higher porosity and water permeabilties from 3.14 to 9.38 L m−2 h−1 bar−1. These membranes were characterized by dialysis, and after 6 h, feed concentration reductions of 2 and 17% for bovine serum albumin and lysozyme, respectively, were observed. In vitro degradation tests showed that a 30% mass loss took place after 90 days of incubation, and a faster initial degradation of spongelike membranes occurred. The spongelike membranes presented a higher maximum stress (12.80 MPa) than the fingerlike membranes (∼6 MPa). With PVP addition, the HFs were less resistant to axial traction and showed a decreased elongation of break from 58 to 23%. © 2017 Wiley Periodicals, Inc. J. Appl. Polym. Sci. 2017, 134, 45494.

Publisher URL: http://onlinelibrary.wiley.com/resolve/doi

DOI: 10.1002/app.45494

You might also like
Discover & Discuss Important Research

Keeping up-to-date with research can feel impossible, with papers being published faster than you'll ever be able to read them. That's where Researcher comes in: we're simplifying discovery and making important discussions happen. With over 19,000 sources, including peer-reviewed journals, preprints, blogs, universities, podcasts and Live events across 10 research areas, you'll never miss what's important to you. It's like social media, but better. Oh, and we should mention - it's free.

  • Download from Google Play
  • Download from App Store
  • Download from AppInChina

Researcher displays publicly available abstracts and doesn’t host any full article content. If the content is open access, we will direct clicks from the abstracts to the publisher website and display the PDF copy on our platform. Clicks to view the full text will be directed to the publisher website, where only users with subscriptions or access through their institution are able to view the full article.