3 years ago

Frontispiece: Gold(I)-Catalysed Asymmetric Hydroamination of Alkenes: A Silver- and Solvent-Dependent Enantiodivergent Reaction

Frontispiece: Gold(I)-Catalysed Asymmetric Hydroamination of Alkenes: A Silver- and Solvent-Dependent Enantiodivergent Reaction
Mostafa Kouach, Xavier Trivelli, Frédéric Capet, Maxence Vandewalle, Eric Génin, Florian Medina, Marc-Antoine Abadie, Francine Agbossou-Niedercorn, Bernhard Linden, Nathalie Duhal, Christophe Michon, Pascal Roussel, Laurent Maron, Iker Del Rosal
In the background is featured Ginkakuji (Silver Pavilion), a Zen temple along Kyoto′s eastern mountains (Higashiyama) in Japan. In the foreground is featured a chemistry sketch based on the Yin and Yang symbol. As many possible dualities (such as light and dark, fire and water…) are thought of as physical manifestations of the duality symbolised by Yin and Yang, parallels can be drawn with organic chemistry and the gold(I)-catalysed asymmetric hydroamination of alkenes. An enantiodivergent reaction is possible depending on the presence of silver. Whereas a gold-catalysed hydroamination reaction afforded (S)-product in toluene, the use of methanol led to an enantioinversion and the generation of (R)-product through solvation of silver and bimetallic activation of the amino-alkene reagent. For more information see the Full Paper by F. Agbossou-Niedercorn, C. Michon and co-workers on page 10777 ff.

Publisher URL: http://onlinelibrary.wiley.com/resolve/doi

DOI: 10.1002/chem.201784564

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