3 years ago

Regio- and Diastereoselective Access to Fused Isoxazolidines via Ru(II)-Catalyzed C–H Activation of Nitrones and Coupling with Perfluoroalkylolefins

Regio- and Diastereoselective Access to Fused Isoxazolidines
via Ru(II)-Catalyzed C–H Activation of Nitrones and Coupling
with Perfluoroalkylolefins
Yuan Liu, Fang Xie, Yunyun Li, Xifa Yang, Xingwei Li
The synthsis of fluorinated isoxazolidines in bicyclic settings has been realized via Ru(II)-catalyzed C–H activation of aryl nitrones with perfluoroalkyl-substituted olefins as the coupling partner. The reaction proceeded via initial chelation-assisted C(aryl)–H allylation followed by regio- and diastereoselective intramolecular dipolar addition between the nitrone directing group and the olefin unit.

Publisher URL: http://dx.doi.org/10.1021/acs.orglett.7b03775

DOI: 10.1021/acs.orglett.7b03775

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