3 years ago

Enantioselective Di-/Perfluoroalkylation of β-Ketoesters Enabled by Cooperative Photoredox/Nickel Catalysis

Enantioselective Di-/Perfluoroalkylation of β-Ketoesters
Enabled by Cooperative Photoredox/Nickel Catalysis
Liang-Qiu Lu, Quan-Quan Zhou, Jing Liu, Dan Liu, Wen-Jing Xiao, Wei Ding
Efficient and enantioselective radical difluoroalkylation and perfluoroalkylation reactions of β-ketoesters were successfully developed through an asymmetric photoredox and nickel catalysis cascade. This protocol provides Rf-containing quaternary stereocenters in up to 67% yield and 95:5 er with ethyl iododifluoroacetate and perfluoroalkyl iodides (C3F7I and C4F9I) as radical sources under extremely mild conditions.

Publisher URL: http://dx.doi.org/10.1021/acs.orglett.7b03826

DOI: 10.1021/acs.orglett.7b03826

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