3 years ago

Metabolic Reprogramming via Targeting CD38 NADase Augments Adoptive T Cell Therapy

Metabolic Reprogramming via Targeting CD38 NADase Augments Adoptive T Cell Therapy
Mario R. Fernandez, John L. Cleveland

One strategy to improve the potency of adoptive T cell therapy is to augment the function and persistence of anti-tumor T cells. In this issue of Cell Metabolism, Chatterjee et al. (2018) demonstrate that intratumoral CD4+ T cell functions and memory can be improved by targeting a CD38-NAD+-Sirt1-Foxo1 metabolic circuit.

Publisher URL: http://www.cell.com/cell-metabolism/fulltext/S1550-4131(17)30727-1

DOI: 10.1016/j.cmet.2017.12.014

You might also like
Never Miss Important Research

Researcher is an app designed by academics, for academics. Create a personalised feed in two minutes.
Choose from over 15,000 academics journals covering ten research areas then let Researcher deliver you papers tailored to your interests each day.

  • Download from Google Play
  • Download from App Store
  • Download from AppInChina

Researcher displays publicly available abstracts and doesn’t host any full article content. If the content is open access, we will direct clicks from the abstracts to the publisher website and display the PDF copy on our platform. Clicks to view the full text will be directed to the publisher website, where only users with subscriptions or access through their institution are able to view the full article.