3 years ago

Telephone-based weight loss support for patients with knee osteoarthritis: a pragmatic randomized controlled trial

To determine the effectiveness of telephone-based weight loss support in reducing the intensity of knee pain in patients with knee osteoarthritis, who are overweight or obese, compared to usual care. Design We conducted a parallel randomized controlled trial (RCT), embedded within a cohort multiple RCT of patients on a waiting list for outpatient orthopaedic consultation at a tertiary referral hospital in NSW, Australia. Patients with knee osteoarthritis, classified as overweight or obese (body mass index between ≥27kg/m2 and <40kg/m2) were randomly allocated to receive referral to an existing non-disease specific government funded 6-month telephone-based weight management and healthy lifestyle service or usual care. The primary outcome was knee pain intensity measured using an 11-point numerical rating scale over 6-month follow-up. A number of secondary outcomes, including self-reported weight were measured. Data analysis was by intention-to-treat according to a pre-published analysis plan. Results Between May 19 and June 30 2015, 120 patients were randomly assigned to the intervention (59 analysed, 1 post-randomization exclusion) or usual care (60 analysed). We found no statistically significant between group differences in pain intensity (area under the curve, mean difference 5.4, 95%CI: -13.7 to 24.5, p=0.58) or weight change at 6 months (self-reported; mean difference -0.4, 95%CI: -2.6 to 1.8, p=0.74). Conclusions Among patients with knee osteoarthritis who are overweight, telephone-based weight loss support, provided using an existing 6-month weight management and healthy lifestyle service did not reduce knee pain intensity or weight, compared with usual care. Trial Registration number ACTRN12615000490572.

Publisher URL: www.sciencedirect.com/science

DOI: S1063458418300104

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