3 years ago

Methylation of Polyols with Trimethylphosphate in the Presence of a Lewis or Brønsted Acid Catalyst

Methylation of Polyols with Trimethylphosphate in the Presence of a Lewis or Brønsted Acid Catalyst
Aurélien Herbinski, Marie-Christine Duclos, Anne-Sophie Mora, Estelle Métay, Marc Lemaire
The alkylation of alcohols and polyols has been investigated with alkylphosphates in the presence of a Lewis or Brønsted acid catalyst. The permethylation of polyols was developed under solvent-free conditions at 100 °C with either iron triflate or Aquivion PW98, affording the isolated products in yields between 52 and 95 %. The methodology was also adjusted to carry out peralkylation with longer alkyl chains. A new polyol methylation process has been developed by using trimethylphosphate and a Lewis or Brønsted acid catalyst, such as iron triflate or Aquivion, respectively. The unreacted trimethylphosphate and the Aquivion resin can be recycled without loss of yield and activity. This methodology can be extend to the ethylation, isopropylation, or butylation of polyols in good yields.

Publisher URL: http://onlinelibrary.wiley.com/resolve/doi

DOI: 10.1002/cssc.201701841

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