3 years ago

Formal Total Syntheses of (−)- and (+)-Actinophyllic Acid

Formal Total Syntheses
of (−)- and (+)-Actinophyllic
Acid
Dan Zhang, Yong Qin, Xiao-Yu Liu, Liping He, Fei Xue, Huifang Lu, Wenfei Li
The formal total syntheses of (−)-actinophyllic acid and its enantiomer starting from the same chiral intermediate are reported. The synthesis features a photoredox organocatalytic asymmetric alkylation to generate the original C15 chirality, a photocatalytic C–H functionalization of 3-methylindole in flow for constructing the C16 all-carbon quaternary center, a regioselective 1,3-dipolar cycloaddition, and an intramolecular Henry reaction to assemble the pentacyclic core of the target molecule.

Publisher URL: http://dx.doi.org/10.1021/acs.joc.7b02747

DOI: 10.1021/acs.joc.7b02747

You might also like
Never Miss Important Research

Researcher is an app designed by academics, for academics. Create a personalised feed in two minutes.
Choose from over 15,000 academics journals covering ten research areas then let Researcher deliver you papers tailored to your interests each day.

  • Download from Google Play
  • Download from App Store
  • Download from AppInChina

Researcher displays publicly available abstracts and doesn’t host any full article content. If the content is open access, we will direct clicks from the abstracts to the publisher website and display the PDF copy on our platform. Clicks to view the full text will be directed to the publisher website, where only users with subscriptions or access through their institution are able to view the full article.