3 years ago

CEST-Dixon for human breast lesion characterization at 3 T: A preliminary study

Ananth J. Madhuranthakam, Stephen Seiler, Shu Zhang, Elena Vinogradov, Emily E. Knippa, Xinzeng Wang, Robert E. Lenkinski, Jochen Keupp
Purpose Chemical exchange saturation transfer (CEST) MRI for breast lesion characterization is promising. However, artifacts are prone to develop in breast CEST imaging as a result of strong lipid signals. The aims of the study are (i) to develop and validate the CEST-Dixon imaging sequence for simultaneous water-fat separation and B0 mapping; and (ii) use the CEST-Dixon method to characterize suspicious lesions in patients undergoing percutaneous biopsy. Methods The gradient-echo multi-echo Dixon acquisition is used to create fat-free CEST and B0 maps. The sequence has been validated in phantoms and in vivo. Five healthy volunteers and 10 patients were scanned to compare the CEST contrast in three frequency ranges centered at 1, 2, and 3.5 ppm. The correlation between the CEST contrast and pathology markers (tumor type, estrogen receptor (ER) status, and Ki-67) was also investigated by stratifying the patients into ER-negative invasive ductal carcinoma (IDC) (more aggressive), ER-positive IDC (less aggressive), and benign groups. Results The CEST-Dixon sequence shows homogenous fat removal in the water-only images. The ER-negative IDC tissues display a trend to higher CEST contrast in all three frequency ranges, whereas the ER-positive IDC, benign, and normal tissues have lower CEST contrast. No significant differences were observed among the ER-positive IDC, benign, and normal tissues. Of the three frequencies ranges, the CEST contrasts at 1 ppm are high in the ER-negative IDC group, have the largest difference among the ER-negative IDC and the other groups, and have the highest correlation with Ki-67. Conclusion Breast CEST-Dixon imaging shows potential to differentiate more aggressive from less aggressive cancers. Magn Reson Med, 2018. © 2018 International Society for Magnetic Resonance in Medicine.

Publisher URL: http://onlinelibrary.wiley.com/resolve/doi

DOI: 10.1002/mrm.27079

You might also like
Discover & Discuss Important Research

Keeping up-to-date with research can feel impossible, with papers being published faster than you'll ever be able to read them. That's where Researcher comes in: we're simplifying discovery and making important discussions happen. With over 19,000 sources, including peer-reviewed journals, preprints, blogs, universities, podcasts and Live events across 10 research areas, you'll never miss what's important to you. It's like social media, but better. Oh, and we should mention - it's free.

  • Download from Google Play
  • Download from App Store
  • Download from AppInChina

Researcher displays publicly available abstracts and doesn’t host any full article content. If the content is open access, we will direct clicks from the abstracts to the publisher website and display the PDF copy on our platform. Clicks to view the full text will be directed to the publisher website, where only users with subscriptions or access through their institution are able to view the full article.