3 years ago

Max-Bergmann award lecture:A RaPID way to discover bioactive nonstandard peptides assisted by the flexizyme and FIT systems

Max-Bergmann award lecture:A RaPID way to discover bioactive nonstandard peptides assisted by the flexizyme and FIT systems
Hiroaki Suga
Although general review articles should cover various people's achievements related to the subject, this review is privileged to describe the technology developed by Suga (and colleagues) as a recipient of the Max-Bergmann Medal in 2016. The technology consists of 3 unique and essential tools, flexizymes, FIT, and RaPID systems. This review describes the history of the development of each tool and discusses the recent applications of the RaPID system to discover potent nonstandard peptides for therapeutic and diagnostic uses. “RaPID (Radom non-standard Peptides Discovery) system. Selective enrichment of binding-active species against a protein of interest is achieved by iterative rounds of selection procedures. The sequences of the enriched pool of mRNAs analyzed by a NGS (next generation sequencer) to reveal the sequences of peptides with potent binding activities, which are synthesized on solid-phase and analyzed by biochemical and biological assays.”

Publisher URL: http://onlinelibrary.wiley.com/resolve/doi

DOI: 10.1002/psc.3055

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