5 years ago

Ion-Exchange Membranes for Stable Derivatization of Protein Crystals

Ion-Exchange Membranes for Stable Derivatization of Protein Crystals
Ana Luı́sa Carvalho, Mariella Polino, Isabel M. Coelhoso, Carla A. M. Portugal, Lina Juknaitė, João G. Crespo, Maria João Romão
In this work, a new method for the derivatization of protein crystals was developed, by using ion-exchange membranes to gently transport ions and heavy atoms to the protein solution. The controlled diffusion regulated by the membrane allows maintaining crystal stability along the process and avoids all the handling procedures, usually performed during conventional soaking.

Publisher URL: http://dx.doi.org/10.1021/acs.cgd.7b00315

DOI: 10.1021/acs.cgd.7b00315

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