3 years ago

In Situ Generation of Quinolinium Ylides from Diazo Compounds: Copper-Catalyzed Synthesis of Indolizine

In Situ Generation of Quinolinium Ylides from Diazo Compounds: Copper-Catalyzed Synthesis of Indolizine
Xiaobing Wan, Yudong Xu, Yanwei Zhao, Hongmei Sun, Ying Shao, Rongxiang Chen, Meihua Ma, Liang Ma
The Cu-catalyzed three-component reaction between quinolines, diazo compounds, and alkenes has been established for direct construction of indolizine derivatives via quinolinium ylides. This methodology is distinguished by the use of a commercially inexpensive catalyst and readily available starting materials, wide substrate scope, and operational simplicity.

Publisher URL: http://dx.doi.org/10.1021/acs.joc.7b01042

DOI: 10.1021/acs.joc.7b01042

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