3 years ago

Synthesis and antimicrobial activity of some heterocyclic compounds bearing benzimidazole and pyrazoline motifs

Darshita Vaja, N. C. Desai, Darshan Pandya

Abstract

A series of 1-(3-(1H-benzoimidazol-2-yl)-5-aryl-4-5dihydro-1H-pyrazol-1-yl)-2-(napthalene-1-yloxy)ethanones (5al) are synthesized and evaluated their antimicrobial activity against gram positive (S. aureus and S. pyogenes), gram negative bacteria (E. coli and P. aeruginosa), and strains of fungi (C. albicans, A. niger, and A. clavatus). Compounds were characterized by spectroscopic techniques such as 1H NMR, 13C NMR, IR, and mass spectroscopy. The newly synthesized compounds 5b, 5i and 5j, 5k showed significant antimicrobial activity against tested microorganisms.

Graphical abstract

Publisher URL: https://link.springer.com/article/10.1007/s00044-017-2040-5

DOI: 10.1007/s00044-017-2040-5

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