3 years ago

Synthesis of Polysubstituted 3-Aminothiophenes from Thioamides and Allenes via Tandem Thio-Michael Addition/Oxidative Annulation and 1,2-Sulfur Migration

Synthesis of Polysubstituted
3-Aminothiophenes
from Thioamides and Allenes via Tandem Thio-Michael Addition/Oxidative
Annulation and 1,2-Sulfur Migration
Yu Wang, Wei-Ping Deng, Teng Han, Xiaoyan Luo, Hong-Liang Li
A facile synthetic method for the construction of 3-aminothiophenes from readily available thioamides and alllenes in the presence of a TBAI/TBHP catalyst system was developed. This protocol represents an efficient and straightforward way to access highly functionalized thiophenes in moderate to excellent yields under mild conditions, via a tandem thio-Michael addition, oxidative annulation, and 1,2-sulfur migration pathway.

Publisher URL: http://dx.doi.org/10.1021/acs.joc.7b02616

DOI: 10.1021/acs.joc.7b02616

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