3 years ago

Discovery of a Novel Potent GPR40 Full Agonist

Discovery of a Novel Potent GPR40 Full Agonist
Compound 12 is a GPR40 agonist that realizes the full magnitude of efficacy possible via GPR40 receptor agonism. In vitro and in vivo studies demonstrated superior glucose lowering by 12 compared to fasiglifam (TAK-875), in a glucose dependent manner. The enhanced efficacy observed with the full agonist 12 was associated with both direct and indirect stimulation of insulin secretion.

Publisher URL: www.sciencedirect.com/science

DOI: S0960894X1830026X

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