3 years ago

Infection is Not Required for Mucoinflammatory Lung Disease in CFTR-knockout Ferrets.

Preston J Anderson, Shashanna R Moll, Scott R Tyler, Xingshen Sun, J Kirk Harris, Nicholas W Keiser, Weihong Zhou, Anthony M Swatek, Maheen Rajput, Jaimie S Gray, Leonard Brooks, Katherine N Gibson-Corley, Eric A Hoffman, Nan He, Kai Wang, R Marshall Pope, Chandler W Jensen-Cody, Yulong Zhang, John F Engelhardt, Yalan Li, Pavana G Rotti, T Idil Apak Evans, Kalpaj R Parekh, Bradley H Rosen, Bo Liang
Classical interpretation of cystic fibrosis (CF) lung disease pathogenesis suggests that infection initiates disease progression, leading to an exuberant inflammatory response, excessive mucus, and ultimately bronchiectasis. While symptomatic antibiotic treatment controls lung infections early in disease, life-long bacterial residence typically ensues. Processes that control the establishment of persistent bacteria in the CF lung, and the contribution of non-infectious components to disease pathogenesis, are poorly understood.

Publisher URL: http://doi.org/10.1164/rccm.201708-1616OC

DOI: 10.1164/rccm.201708-1616OC

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