3 years ago

Dramatic Changes in Malaria Population Genetic Complexity in Dielmo and Ndiop, Senegal, Revealed Using Genomic Surveillance.

Dyann F Wirth, Sarah K Volkman, Souleymane Doucoure, Daouda Ndiaye, Makhtar Niang, Cheikh Talla, Amy K Bei, Adama Tall, Joseph Faye, Fatoumata D Sarr, Awa B Deme, Nafissatou Diagne, Daniel L Hartl, Aissatou Toure-Balde, Cheikh Sokhna, Rachel F Daniels, Souleymane Mboup
Dramatic changes in transmission intensity can impact Plasmodium population diversity. Using samples from 2 distant time-points in the Dielmo/Ndiop longitudinal cohorts from Senegal, we applied a molecular barcode tool to detect changes in parasite genotypes and complexity of infection that corresponded to changes in transmission intensity. We observed a striking statistically significant difference in genetic diversity between the 2 parasite populations. Furthermore, we identified a genotype in Dielmo and Ndiop previously observed in Thiès, potentially implicating imported malaria. This genetic surveillance study validates the molecular barcode as a tool to assess parasite population diversity changes and track parasite genotypes.

Publisher URL: http://doi.org/10.1093/infdis/jix580

DOI: 10.1093/infdis/jix580

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