3 years ago

Efficient generation of complete sequences of MDR-encoding plasmids by rapid assembly of MinION barcoding sequencing data.

Sheng Chen, Edward Wai-Chi Chan, Miaomiao Xie, Ning Dong, Marcus Ho Yin Wong, Xuemei Yang, Dachuan Lin, Ruichao Li
Multidrug resistance (MDR)-encoding plasmids are considered major molecular vehicles responsible for transmission of antibiotic resistance genes among bacteria of the same or different species. Delineating the complete sequences of such plasmids could provide valuable insight into the evolution and transmission mechanisms underlying bacterial antibiotic resistance development. However, due to the presence of multiple repeats of mobile elements, complete sequencing of MDR plasmids remains technically complicated, expensive and time-consuming.

Publisher URL: http://doi.org/10.1093/gigascience/gix132

DOI: 10.1093/gigascience/gix132

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