Self-Templated Stepwise Synthesis of Monodispersed Nanoscale Metalated Covalent Organic Polymers for In Vivo Bioimaging and Photothermal Therapy

4 years ago

Self-Templated Stepwise Synthesis of Monodispersed Nanoscale Metalated Covalent Organic Polymers for In Vivo Bioimaging and Photothermal Therapy

Ziyong Cheng, Bin Liu, Ping'an Ma, Jun Lin, Maolin Pang, Shouxin Bao, Yanshu Shi, Xiaoran Deng, Bei Liu

Size- and shape-controlled growth of nanoscale microporous organic polymers (MOPs) is a big challenge scientists are confronted with; meanwhile, rendering these materials for in vivo biomedical applications is still scarce. In this study, a monodispersed nanometalated covalent organic polymer (MCOP, M=Fe, Gd) with sizes around 120 nm was prepared by a self-templated two-step solution-phase synthesis method. The metal ions (Fe3+, Gd3+) played important roles in generating a small particle size and in the functionalization of the products during the reaction with p-phenylenediamine (Pa). The resultant Fe-Pa complex was used as a template for the subsequent formation of MCOP following the Schiff base reaction with 1,3,5-triformylphloroglucinol (Tp). A high tumor suppression efficiency for this Pa-based COP is reported for the first time. This study demonstrates the potential use of MCOP as a photothermal agent for photothermal therapy (PTT) and also provides an alternative route to fabricate nano-sized MCOPs. I'm a MCOP: A monodispersed nanometallated covalent organic polymer (MCOP, M=Fe, Gd) based on p-phenylenediamine (Pa) and 1,3,5-triformylphloroglucinol (Tp) was prepared by a self-templated two-step solution-phase synthesis method at room temperature. The photothermal therapy (PTT) efficacy was assessed both in vitro and in vivo, and high tumor suppression efficiency for this Pa-based COP is reported.

Publisher URL: http://onlinelibrary.wiley.com/resolve/doi

DOI: 10.1002/asia.201700796