3 years ago

Thermosensitive Triterpenoid-Appended Polymers with Broad Temperature Tunability Regulated by Host–Guest Chemistry

Thermosensitive Triterpenoid-Appended Polymers with Broad Temperature Tunability Regulated by Host–Guest Chemistry
Jun Hu, Yong Ju, Yuxia Gao, Jie Hao, Qiang Yan, Ying Li
Thermoresponsive water-soluble polymers are of great importance since they typically show a lower critical solution temperature (LCST) in aqueous media. In this research, the LCST change in broad temperature ranges of copolymers composed of natural glycyrrhetinic acid (GA)-based methacrylate and N,N′-dimethylacrylamides (DMAs) was investigated as a function of the concentration and the content of GA pendants. By complexation of GA pendants with β-cyclodextrin (β-CD), a side-chain polypseudorotaxane was obtained, which exhibited a significant increase in the LCST of copolymers. Moreover, the precisely reversible control of the LCST behavior was realized through adding a competing guest molecule, sodium 1-admantylcarboxylate. This work illustrates a simple and effective approach to endow water-soluble polymers with broad temperature tunability and helps us further understand the effect of a biocompatible host–guest complementary β-CD/GA pair on the thermoresponsive process. Be our guest: A simple and effective approach to endow water-soluble polymers with broad temperature tunability regulated by host–guest chemistry of natural products is described (see figure).

Publisher URL: http://onlinelibrary.wiley.com/resolve/doi

DOI: 10.1002/asia.201700581

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