3 years ago

Necrosis in anti-SRP+ and anti-HMGCR+myopathies: Role of autoantibodies and complement.

Norman Zerbe, Nicolas Champtiaux, Aude Rigolet, Werner Stenzel, Laurent Drouot, Helena Radbruch, Damien Amelin, Sarah Louis-Leonard, Thierry Maisonobe, Kuberaka Mariampillai, Olivier Boyer, Cecile Bergua, Bruno Eymard, Corinna Preusse, Louiza Arouche-Delaperche, Charles Duyckaerts, Hans-Hilmar Goebel, Gillian Butler-Browne, Peter Hufnagl, Olivier Benveniste, Yves Allenbach
To characterize muscle fiber necrosis in immune-mediated necrotizing myopathies (IMNM) with anti-signal recognition particle (SRP) or anti-3-hydroxy-3-methylglutarylcoenzyme A reductase (HMGCR) antibodies and to explore its underlying molecular immune mechanisms.

Publisher URL: http://doi.org/10.1212/WNL.0000000000004923

DOI: 10.1212/WNL.0000000000004923

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