3 years ago

Synthesis of Substituted 2-Amino-1,3-oxazoles via Copper-Catalyzed Oxidative Cyclization of Enamines and N,N-Dialkyl Formamides

Synthesis of Substituted 2-Amino-1,3-oxazoles via Copper-Catalyzed Oxidative Cyclization of Enamines and N,N-Dialkyl Formamides
Peng Gao, Zijing Bai, Juan Wang, Desuo Yang, Zheng-Hui Guan, Ming-Jin Fan
A facile synthesis of 2-amino-1,3-oxazoles via CuI-catalyzed oxidative cyclization of enamines and N,N-dialkyl formamides has been developed. The reaction proceeds through an oxidative C−N bond formation, followed by an intramolecular C(sp2)−H bond functionalization/C−O cyclization in one pot. This protocol provides direct access to useful 2-amino-1,3-oxazoles and features protecting-group-free nitrogen sources, readily available starting materials, a broad substrate scope and mild reaction conditions. A one-pot synthesis of 2-amino-1,3-oxazoles via CuI-catalyzed oxidative cyclization of enamines and N,N-dialkyl formamides has been developed. This protocol provides direct access to useful 2-amino-1,3-oxazoles and features protecting-group-free nitrogen sources, readily available starting materials, a broad substrate scope and mild reaction conditions.

Publisher URL: http://onlinelibrary.wiley.com/resolve/doi

DOI: 10.1002/asia.201700503

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