3 years ago

PPh3 Mediated Reductive Annulation Reaction between Isatins and Electron Deficient Dienes to Construct Spirooxindole Compounds

PPh3 Mediated Reductive Annulation Reaction between Isatins and Electron Deficient Dienes to Construct Spirooxindole Compounds
Lei Zhang, Peng-Fei Xu, Guo-Qiang Xu, Zhu-Yin Wang, Hong Lu
A PPh3 mediated reductive annulation reaction between isatins and 4,4-dicyano-2-methylenebut-3-enoates was developed. The reaction provided an alternative method for constructing five- and three-membered all-carbon spirooxindole compounds. Lithium chloride as a Lewis acid played a key role in the synthesis of spirocyclopentenyl oxindole compounds.

Publisher URL: http://dx.doi.org/10.1021/acs.joc.7b00595

DOI: 10.1021/acs.joc.7b00595

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