Journal of the American Chemical Society
Journal of the American Chemical Society
5 years ago

Rh-Catalyzed Anti-Markovnikov Hydrocyanation of Terminal Alkynes

Rh-Catalyzed Anti-Markovnikov Hydrocyanation of Terminal Alkynes
Fei Ye, Tobias Ritter, Junting Chen
We report the first highly stereo- and regioselective hydrocyanation of terminal alkynes to furnish E-configured alkenyl nitriles. Acrylonitriles can be accessed on gram scale with broad substrate scope and functional group tolerance. The hydrocyanation reaction employs acetone cyanohydrin as a practical alternative to HCN gas.

Publisher URL: http://dx.doi.org/10.1021/jacs.7b03749

DOI: 10.1021/jacs.7b03749

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