Accounts of Chemical Research
Accounts of Chemical Research
5 years ago

Discovery and Biosensing Applications of Diverse RNA-Cleaving DNAzymes

Discovery and Biosensing Applications of Diverse RNA-Cleaving DNAzymes
Yingfu Li, Dingran Chang, Meng Liu
DNA-based enzymes, or DNAzymes, are not known to exist in Nature but can be isolated from random-sequence DNA pools using test tube selection techniques. Since the report of the first DNAzyme in 1994, many catalytic DNA molecules for catalyzing wide-ranging chemical transformations have been isolated and studied. Our laboratory has a keen interest in searching for diverse DNAzymes capable of cleaving RNA-containing substrates, determining their sequence requirements and structural properties, and examining their potential as biosensors.

Publisher URL: http://dx.doi.org/10.1021/acs.accounts.7b00262

DOI: 10.1021/acs.accounts.7b00262

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