3 years ago

Investigating causal associations between use of nicotine, alcohol, caffeine, and cannabis: A two-sample bidirectional Mendelian randomization study.

Jorien L Treur, Jacqueline M Vink, Karin J H Verweij
Epidemiological studies consistently show co-occurrence of use of different addictive substances. Whether these associations are causal or due to overlapping underlying influences remains an important question in addiction research. Methodological advances have made it possible to use published genetic associations to infer causal relationships between phenotypes. In this exploratory study, we used Mendelian randomization (MR) to examine the causality of well-established associations between nicotine, alcohol, caffeine, and cannabis use.

Publisher URL: http://doi.org/10.1111/add.14154

DOI: 10.1111/add.14154

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