3 years ago

Aurora Kinase Inhibitors In Head And Neck Cancer.

Tian Liu, Sisi Mi, Jing Liu, Yasusei Kudo, Takaaki Tsunematsu, Wenhua Shao, Naozumi Ishimaru, Guangying Qi, Bo Tang, Shengjian Jin
Aurora kinases are a group of serine/threonine kinases responsible for the regulation of mitosis. In recent years, with the increase in Aurora kinase-related research, the important role of Aurora kinases in tumorigenesis has been gradually recognized. Aurora kinases have been regarded as a new target for cancer therapy, resulting in the development of Aurora kinase inhibitors. The study and application of these small-molecule inhibitors, especially in combination with chemotherapy drugs, represents a new direction in cancer treatment. This paper reviews studies on Aurora kinases from recent years, including studies of their biological function, their relationship with tumor progression, and their inhibitors.

Publisher URL: http://doi.org/10.2174/1568026618666180112163741

DOI: 10.2174/1568026618666180112163741

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