3 years ago

Artificial Cysteine S-Glycosylation Induced by Per-O-Acetylated Unnatural Monosaccharides during Metabolic Glycan Labeling

Artificial Cysteine S-Glycosylation Induced by Per-O-Acetylated Unnatural Monosaccharides during Metabolic Glycan Labeling
Pinou Lv, Yuan Liu, Bo Cheng, Weiyao Hong, Xinqi Fan, Wen Zhou, Chu Wang, Xing Chen, Mengting Han, Linghang Peng, Yuntao Zhu, Yifei Du, Ke Qin, Rongbing Huang, Wei Qin
Peracetylated unnatural sugars—the “arrows” used by glycoscientists for decades to label cellular glycans—can induce artificial cysteine glycosylation on various proteins, as reported in the Communication (DOI: 10.1002/anie.201711710) by C. Wang, X. Chen et al. This “off-targeting” of the per-O-acetylated sugar reporters can be likened to Cao Cao shooting arrows at scarecrows and straw boats in the fictitious story “Romance of the Three Kingdoms”, and calls for caution in the use of peracetylated sugars and the development of better versions.

Publisher URL: http://onlinelibrary.wiley.com/resolve/doi

DOI: 10.1002/anie.201800116

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