3 years ago

A Representative Synthetic Route for C5 Angucycline Glycosides: Studies Directed toward the Total Synthesis of Mayamycin

A Representative Synthetic
Route for C5 Angucycline
Glycosides: Studies Directed toward the Total Synthesis of Mayamycin
Soumen Chakraborty, Dipakranjan Mal
This study discloses an efficient synthetic route for the regiospecific construction of a C5 glycoside angucycline representative of mayamycin. The key steps are intramolecular aldol condensation and Hauser annulation, and the key precursor for the aldol reaction is accessible through utilization of α-lithiation of a vinyl ether.

Publisher URL: http://dx.doi.org/10.1021/acs.joc.7b02833

DOI: 10.1021/acs.joc.7b02833

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