3 years ago

Cu-catalyzed Cascade Cyclization of Isothiocyanates, Alkynes, and Diaryliodonium Salts: Access to Diversely Functionalized Quinolines

Cu-catalyzed Cascade Cyclization of Isothiocyanates, Alkynes, and Diaryliodonium Salts: Access to Diversely Functionalized Quinolines
Salman Khan, Chandra M. R. Volla
Herein, we report a copper-catalyzed novel, highly efficient, and modular cascade annulation reaction for the synthesis of quinoline derivatives starting from easily available alkynes, isothiocyanates, and diaryliodonium salts. The reaction displayed excellent regioselectivities, when unsymmetrical alkynes were employed as partners, giving access to diversely functionalized quinolines in good to excellent yields for a wide range of functional groups. Three in three: Herein, we describe a novel and highly efficient copper-catalyzed three-component cascade cyclization reaction, involving the formation of three new bonds for the synthesis of functionalized 2-arylthio quinolines in good to excellent yields.

Publisher URL: http://onlinelibrary.wiley.com/resolve/doi

DOI: 10.1002/chem.201702364

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