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5 years ago

Laser-Induced Focused Ultrasound for Cavitation Treatment: Toward High-Precision Invisible Sonic Scalpel

Laser-Induced Focused Ultrasound for Cavitation Treatment: Toward High-Precision Invisible Sonic Scalpel
Taehwa Lee, Hakan Demirci, L. Jay Guo, Qiaochu Li, Wei Luo
Beyond the implementation of the photoacoustic effect to photoacoustic imaging and laser ultrasonics, this study demonstrates a novel application of the photoacoustic effect for high-precision cavitation treatment of tissue using laser-induced focused ultrasound. The focused ultrasound is generated by pulsed optical excitation of an efficient photoacoustic film coated on a concave surface, and its amplitude is high enough to produce controllable microcavitation within the focal region (lateral focus <100 µm). Such microcavitation is used to cut or ablate soft tissue in a highly precise manner. This work demonstrates precise cutting of tissue-mimicking gels as well as accurate ablation of gels and animal eye tissues. A high-precision sonic scalpel is demonstrated using microcavitation generated by a laser-induced focused ultrasound. Rapid growth of microbubbles causes strain in surrounding tissue, ablating it and destroying the tissue structures. Owing to the controllable microcavitation, such sonic ablation would be applicable for high-precision, targeted treatment of diseased tissue.

Publisher URL: http://onlinelibrary.wiley.com/resolve/doi

DOI: 10.1002/smll.201701555

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