3 years ago

Localised inflammatory reactions at sites of subcutaneous methotrexate injections during treatment with ultraviolet B

P. M. Farr, S. Muthiah, F. Charlton
Ultraviolet B (UVB) phototherapy may be used in combination with methotrexate to treat psoriasis. When given in high doses as chemotherapy, methotrexate can induce a “radiation recall” reaction where a rash develops at sites of previous exposure to sunlight or radiotherapy, and where keratinocyte necrosis is a prominent histopathological finding1. However, this reaction does not seem to occur when methotrexate, given orally in conventional dermatological doses, is combined with UVB2, 3. This article is protected by copyright. All rights reserved.

Publisher URL: http://onlinelibrary.wiley.com/resolve/doi

DOI: 10.1111/bjd.16357

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