3 years ago

HIV Immunogens: Affinity Is Key

HIV Immunogens: Affinity Is Key
Savit Prabhu, Ian A. Cockburn, Carola G. Vinuesa

Generation of broadly neutralizing antibodies is a key aim of HIV vaccine design, but the precursor B cells are rare. Abbott et al. (2018) report that high affinity and avidity immunogens are required to promote maturation of low frequency B cells in germinal centers.

Publisher URL: http://www.cell.com/immunity/fulltext/S1074-7613(18)30002-5

DOI: 10.1016/j.immuni.2018.01.002

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