3 years ago

FAS-associated factor-1 positively regulates type I interferon response to RNA virus infection by targeting NLRX1

Jae-Hoon Kim, Tae-Hwan Kim, Chul-Joong Kim, Md Bashir Uddin, Jong-Soo Lee, Min-Eun Park, Jae U. Jung, Chamilani Nikapitiya, Jin Yeul Ma, Hyun-Cheol Lee, Eunhee Kim

by Jae-Hoon Kim, Min-Eun Park, Chamilani Nikapitiya, Tae-Hwan Kim, Md Bashir Uddin, Hyun-Cheol Lee, Eunhee Kim, Jin Yeul Ma, Jae U. Jung, Chul-Joong Kim, Jong-Soo Lee

FAS-associated factor-1 (FAF1) is a component of the death-inducing signaling complex involved in Fas-mediated apoptosis. It regulates NF-κB activity, ubiquitination, and proteasomal degradation. Here, we found that FAF1 positively regulates the type I interferon pathway. FAF1gt/gt mice, which deficient in FAF1, and FAF1 knockdown immune cells were highly susceptible to RNA virus infection and showed low levels of inflammatory cytokines and type I interferon (IFN) production. FAF1 was bound competitively to NLRX1 and positively regulated type I IFN signaling by interfering with the interaction between NLRX1 and MAVS, thereby freeing MAVS to bind RIG-I, which switched on the MAVS-RIG-I-mediated antiviral signaling cascade. These results highlight a critical role of FAF1 in antiviral responses against RNA virus infection.

Publisher URL: http://journals.plos.org/plosone/article

DOI: 10.1371/journal.ppat.1006398

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