3 years ago

High prevalence of Non-B HIV-1 subtypes in overseas sailors and prostitutes in Korea.

Brian Thomas Foley, Jung Eun Kim, Young-Keol Cho
There have been no studies related to groups at the highest risk for HIV-1 infection in Korea before 1993. Here, for the first time, we report the distribution of HIV subtypes in overseas sailors (OSs), and prostitutes who worked in brothels near US military bases in Korea. We retrospectively determined the sequences of nef in 131 patients using RT-PCR. These patients comprised of 102 OSs, 14 OS spouses, and 15 prostitutes. Phylogenetic analysis was performed using 128 Korean OSs, OS spouses, and prostitutes. The distribution of non-B subtypes (n = 105) was as follows: 39, CRF02_AG; 15, CRF01_AE; 7, A1; 7, A2; 6, D; 2, CRF06_cpx; 3, C; 6, G; 11, untypable, and 1 each for CRF09_cpx, CRF12_BF, CRF50_A1D, A3, AFG, H, F1, F2 , and A. Of the 116 OSs and OS spouses, 101 (87%), 11 (9%), and 4 (3%) subjects had non-B, Western B, and Korean subclade B (KSB) HIV-1s, respectively. Among the 15 prostitutes, 10 had Western B (67%), 4 non-B (27%), and 1 KSB (7%) HIV-1s. All 14 couples, each comprising of an OS and his spouse, had the same subtype. KSB (5%) was detected in OSs and prostitutes in 1990 and 1994, respectively. Of the 131 patients analyzed in this study, 105 (80%), 21 (16%), and 5 (4%) were infected with the non-B, Western B, and KSB subtypes of HIV, respectively. In future, these data may provide an important foundation for analysis of HIV-1 subtypes in Korea.

Publisher URL: http://doi.org/10.1089/AID.2017.0238

DOI: 10.1089/AID.2017.0238

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