3 years ago

Biomechanical Rigidity and Quantitative Proteomics Analysis of Segmental Regions of the Trabecular Meshwork at Physiologic and Elevated Pressures.

Julia A Staverosky, Ashok P Reddy, Janice A Vranka, Ted S Acott, Paul Russell, Phillip A Wilmarth, Vijay Krishna Raghunathan, Larry L David
The extracellular matrix (ECM) of the trabecular meshwork (TM) modulates resistance to aqueous humor outflow, thereby regulating IOP. Glaucoma, a leading cause of irreversible blindness worldwide, is associated with changes in the ECM of the TM. The elastic modulus of glaucomatous TM is larger than age-matched normal TM; however, the biomechanical properties of segmental low (LF) and high flow (HF) TM regions and their response to elevated pressure, are unknown.

Publisher URL: http://doi.org/10.1167/iovs.17-22759

DOI: 10.1167/iovs.17-22759

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