3 years ago

The immunosuppressive effects of CD4+CD25+ regulatory T cells on dendritic cells in patients with chronic hepatitis B

Yuan Fang, Xue-bing Yan, Yin-yue Shi, Pei-pei Zhou, Gui-ping Wu, Ming-jia Dai, Juan Xu
The characteristics and functions of CD4+CD25+ regulatory T cells (Tregs) have been well defined in murine and human systems. However, the interaction or cross-talk between CD4+CD25+ Tregs and dendritic cells (DCs) remains controversial. In this study, the effects of chronic hepatitis B (CHB) CD4+CD25+ Tregs on the maturation and function of monocyte-derived DCs were examined. The results showed that CD4+CD25+ render the DCs inefficient as antigen-presenting cells (APCs) despite prestimulation with CD40 ligand. This effect was marginally reverted by applying neutralizing antibodies (Abs) to IL-10 and TGF-β. There was an increased IL-10 and TGF-βsecretion and reduced expression of costimulatory molecules in DC. Thus, in addition to a direct suppressor effect on CD4+T cells, CD4+CD25+ may modulate the immune response through DCs in CHB patients. This article is protected by copyright. All rights reserved.

Publisher URL: http://onlinelibrary.wiley.com/resolve/doi

DOI: 10.1111/jvh.12863

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