3 years ago

Construction of giant glycosidase inhibitors from iminosugar-substituted fullerene macromonomers

Construction of giant glycosidase inhibitors from iminosugar-substituted fullerene macromonomers
Anne Bodlenner, M. Isabel Garcia-Moreno, Thi Minh Nguyet Trinh, Philippe Compain, Jeremy P. Schneider, Carmen Ortiz Mellet, Michel Holler, Jean-Francois Nierengarten, Jose M. Garcia Fernandez
A dramatic enhancement in the glycosidase multivalent inhibitory effect was observed while going from a dodecavalent iminosugar ball to the corresponding giant molecule with 120 peripheral subunits.
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