3 years ago

The Role of E6 Spliced Isoforms (E6*) in Human Papillomavirus-Induced Carcinogenesis.

Adriana Contreras-Paredes, Leslie Olmedo-Nieva, Marcela Lizano, J Omar Muñoz-Bello
Persistent infections with High Risk Human Papillomaviruses (HR-HPVs) are the main cause of cervical cancer development. The E6 and E7 oncoproteins of HR-HPVs are derived from a polycistronic pre-mRNA transcribed from an HPV early promoter. Through alternative splicing, this pre-mRNA produces a variety of E6 spliced transcripts termed E6*. In pre-malignant lesions and HPV-related cancers, different E6/E6* transcriptional patterns have been found, although they have not been clearly associated to cancer development. Moreover, there is a controversy about the participation of E6* proteins in cancer progression. This review addresses the regulation of E6 splicing and the different functions that have been found for E6* proteins, as well as their possible role in HPV-induced carcinogenesis.

Publisher URL: http://doi.org/10.3390/v10010045

DOI: 10.3390/v10010045

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